Viral Epitranscriptomics
نویسندگان
چکیده
منابع مشابه
Global Epitranscriptomics Profiling of RNA Post-Transcriptional Modifications as an Effective Tool for Investigating the Epitranscriptomics of Stress Response.
The simultaneous detection of all the post-transcriptional modifications (PTMs) that decorate cellular RNA can provide comprehensive information on the effects of changing environmental conditions on the entire epitranscriptome. To capture this type of information, we performed the analysis of ribonucleotide mixtures produced by hydrolysis of total RNA extracts from S. cerevisiae that was grown...
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Epigenetic modifications of DNA and chromatin are long known to control stem cell differentiation and organ function but the role of similar modifications at the level or regulatory RNAs is just beginning to emerge. Over 160 RNA modifications have been identified but their abundance, distribution and functional significance are not known. The few available maps of RNA modifications indicated th...
متن کاملEpitranscriptomics: Toward A Better Understanding of RNA Modifications
Ever since the first RNA nucleoside modification was characterized in 1957 [1], over 100 distinct chemical modifications have been identified in RNA to date [2]. Most of these modifications were characterized in non-coding RNAs (ncRNAs), including tRNA, rRNA, and small nuclear RNA (snRNA) [3]. Studies in the past few decades have located various modifications in these ncRNAs and revealed their ...
متن کاملErratum: Profiling ribonucleotide modifications at full-transcriptome level: a step toward MS-based epitranscriptomics.
The elucidation of the biological significance of RNA post-transcriptional modifications is hampered by the dearth of effective high-throughput sequencing approaches for detecting, locating, and tracking their levels as a function of predetermined experimental factors. With the goal of confronting this knowledge gap, we devised a strategy for completing global surveys of all ribonucleotide modi...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2017
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.02263-16